The novel caprine parainfluenza virus type 3 showed pathogenicity in Guinea pigs

doi:10.1016/j.micpath.2019.103569

	The novel caprine parainfluenza virus type 3 showed pathogenicity in Guinea pigs
	Hao, Fei ; Wang, Zhongyu; Mao, Li; Yang, Leilei ; Zhang, Wenwen ; Li, Jizong ; Wang, Xuyuan ; Li, Wenliang ; Jiang, Jieyuan
	2019-09
发表期刊	MICROBIAL PATHOGENESIS
卷号	134
摘要	Caprine parainfluenza virus type 3 (CPIV3) is one of the important viral respiratory tract agents in goats. The pathogenicity of CPIV3 has been examined in goats but it has not been explored in other laboratory animals. In the present study, an experimental infection of guinea pigs with CPIV3 was performed. The virus-inoculated guinea pigs displayed clinical signs related to the respiratory disease at 2-12 days post inoculation (dpi). Five infected guinea pigs died during 2 and 7 dpi. Apparent gross pneumonic lesions including consolidation and congestion in one or more lung lobes were observed in necropsied and dead animals. Histo-pathological changes in lungs including expansions of the alveolar interstitium, congestion, macrophage infiltration and compensatory emphysema were also observed. Virus was detectable at 2-10 dpi, 2-10 dpi and 2-7 dpi, as detected by virus isolation, real-time RT-PCR and immunohistochemistry staining, respectively. Viremia was also confirmed after CPIV3 infection during 3-7 dpi. The severe pathological lesions and highest viral load were observed before 7 dpi. Viral specific hemagglutination inhibition and neutralizing antibodies were produced from 7 dpi and 10 dpi, respectively, which related to the clearance of virus. The results present here indicated that guinea pig could be an ideal laboratory animal model for CPIV3 studies in the future.
关键词	Caprine parainfluenza virus type 3 Guinea pigs Pathogenicity Respiratory disease
DOI	10.1016/j.micpath.2019.103569
收录类别	SCI ; SCOPUS ; SCIE
ISSN	0882-4010
语种	英语
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
WOS记录号	WOS:000483008700008
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
原始文献类型	Article
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.lzufe.edu.cn/handle/39EH0E1M/10562
专题	财税与公共管理学院外语学院
作者单位	1.Minist Agr & Rural Affairs, Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Bioprod Engn, Nanjing 210014, Jiangsu, Peoples R China; 2.Lanzhou Univ Finance & Econ, Inst Int Educ, Lanzhou 730020, Gansu, Peoples R China; 3.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China; 4.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China; 5.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Hao, Fei,Wang, Zhongyu,Mao, Li,et al. The novel caprine parainfluenza virus type 3 showed pathogenicity in Guinea pigs[J]. MICROBIAL PATHOGENESIS,2019,134.
APA	Hao, Fei.,Wang, Zhongyu.,Mao, Li.,Yang, Leilei.,Zhang, Wenwen.,...&Jiang, Jieyuan.(2019).The novel caprine parainfluenza virus type 3 showed pathogenicity in Guinea pigs.MICROBIAL PATHOGENESIS,134.
MLA	Hao, Fei,et al."The novel caprine parainfluenza virus type 3 showed pathogenicity in Guinea pigs".MICROBIAL PATHOGENESIS 134(2019).

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