Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance

doi:10.1007/s10473-024-0321-x

	Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance
	Bao, Kangbo1,2 ; Liang, Guizhen 3; Tian, Tianhai 4; Zhang, Xinan 2
	2024-05
发表期刊	ACTA MATHEMATICA SCIENTIA
卷号	44 期号:3 页码:1165-1188
摘要	Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases. It has also been demonstrated to be related to cancer heterogeneity, which promotes the emergence of treatment-refractory cancer cell populations. Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system, we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting. We analyze the local geometric properties of the equilibria of the model. Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population. Moreover, the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength. Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.
关键词	mathematical model drug resistance cancer heterogeneity immune system targeted therapy
DOI	10.1007/s10473-024-0321-x
收录类别	SCIE
ISSN	0252-9602
语种	英语
WOS研究方向	Mathematics
WOS类目	Mathematics
WOS记录号	WOS:001163620000012
出版者	SPRINGER
原始文献类型	Article
来源期刊等级	C1类
EISSN	1572-9087
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.lzufe.edu.cn/handle/39EH0E1M/35674
专题	信息工程与人工智能学院
通讯作者	Zhang, Xinan
作者单位	1.Lanzhou Univ Finance & Econ, Sch Informat Engn & Artificial Intelligence, Lanzhou 730020, Peoples R China; 2.Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China; 3.Xinxiang Univ, Sch Math & Informat Sci, Xinxiang 453003, Henan, Peoples R China; 4.Monash Univ, Sch Math Sci, Melbourne, Vic 3800, Australia
第一作者单位	兰州财经大学
推荐引用方式 GB/T 7714	Bao, Kangbo,Liang, Guizhen,Tian, Tianhai,et al. Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance[J]. ACTA MATHEMATICA SCIENTIA,2024,44(3):1165-1188.
APA	Bao, Kangbo,Liang, Guizhen,Tian, Tianhai,&Zhang, Xinan.(2024).Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance.ACTA MATHEMATICA SCIENTIA,44(3),1165-1188.
MLA	Bao, Kangbo,et al."Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance".ACTA MATHEMATICA SCIENTIA 44.3(2024):1165-1188.